Scientists have embarked on renewed investigations into androgen therapy — a former breast cancer treatment. Recent research in mice shows that it may help block tumor growth. As the American Cancer Society report, breast cancer is one of the most common forms of the disease among women. It can be very aggressive and is responsible for the second-highest number of cancer deaths in this population. Scientists continue to search for methods of prevention and treatment. The latest investigation indicates that a decades-old treatment ultimately considered more harmful than helpful may, in fact, be instrumental in suppressing breast cancer tumors.
Study: Androgen Therapy Shows Promise as a Breast Cancer Treatment
Counseling and Support Groups for Metastatic Breast Cancer
Scientists at the University of Turku Bioscience Center in Finland have recently identified that a protein trafficking receptor studied mainly in neurons, plays an essential role in breast cancer metastasis. The research team observed that the Sortilin-related receptor SorLA functionally contributes to the most reported therapy-resistant mechanism by which the cell-surface receptor HER3 counteracts HER2 targeting therapy in HER2-positive cancers. Moreover, the Finnish researchers showed that removing SorLA from cancer cells sensitized anti-HER2 resistant breast cancer brain metastasis to targeted therapy. HER2 protein is a strong driver of tumor growth. HER2 targeting therapies, such as Herceptin, are widely used in clinical care and it plays an important role in the treatment of HER2-positive cancers. To date, very little has been known about SorLA in cancer. Our discovery that HER3 receptor-induced drug resistance is dependent on SorLA was surprising since this cancer type and its resistance mechanisms have already been widely studied.
Cancer Genetics Risk Assessment and Counseling (PDQ®)–Health Professional Version
Metastatic breast cancer also called stage IV or advanced breast cancer is not a specific type of breast cancer. Metastatic breast cancer is breast cancer that has spread beyond the breast and nearby lymph nodes to other parts of the body most often the bones, lungs, liver or brain. For example, breast cancer that has spread to the bones is still breast cancer not bone cancer.
External beam radiation uses high-powered beams of energy to kill cancer cells. Beams of radiation are precisely aimed at the cancer using a machine that moves around your body. Radiation therapy for breast cancer uses high-energy X-rays, protons or other particles to kill cancer cells. Rapidly growing cells, such as cancer cells, are more susceptible to the effects of radiation therapy than are normal cells. The X-rays or particles are painless and invisible.