Growth hormone GH or somatotropin , also known as human growth hormones hGH or HGH in its human form, is a peptide hormone that stimulates growth, cell reproduction, and cell regeneration in humans and other animals. It is thus important in human development. GH also stimulates production of IGF-1 and increases the concentration of glucose and free fatty acids. GH is a amino acid , single-chain polypeptide that is synthesized, stored and secreted by somatotropic cells within the lateral wings of the anterior pituitary gland.
Medications for Adult Human Growth Hormone Deficiency
Growth Hormone Deficiency Symptoms
Objective: To review whether growth hormone GH therapy should be continued into young adulthood, beyond achievement of final height, when GH deficiency persists, to summarize the recent evidence of the benefits of GH treatment during the transition period, and to address currently debated issues involving diagnosis, treatment, and transition of care. Methods: Primary literature was reviewed in the following areas: the benefits and risks of GH therapy during the transition period, the diagnostic criteria for GH deficiency and recommended testing procedures during transition, the optimal dose of GH therapy during transition, and the factors to consider in the transition of care from the pediatric to the adult endocrinologist. Results: Studies support the continuation of GH therapy through the transition period until accrual of peak bone mass, rather than cessation of GH treatment when adult height has been achieved. Continued GH treatment in patients with persistent GH deficiency after achieving final height has been associated with significant additional bone maturation and improved overall metabolic profile.
U.S. Food and Drug Administration
Growth hormone deficiency GHD is a condition wherein the pituitary gland fails to produce enough growth hormones. While this is a condition common in children, adults can acquire this later in life as well. What is the pituitary gland?
Growth hormone GH is the most important hormonal regulator of postnatal longitudinal growth in man. In adults GH is no longer needed for longitudinal growth. Adults with growth hormone deficiency GHD are characterised by perturbations in body composition, lipid metabolism, cardiovascular risk profile and bone mineral density. It is well established that adult GHD usually is accompanied by an increase in fat accumulation and GH replacement in adult patients with GHD results in reduction of fat mass and abdominal fat mass in particular. It is also recognized that obesity and abdominal obesity in particular results in a secondary reduction in GH secretion and subnormal insulin-like growth factor-I IGF-I levels.