For some, sipping cocktails does more than just get you tipsy—it turns your skin beet red. It all depends on your gene pool and whether it contains a mutant or altered form of the ALDH2 aldehyde dehydrogenase 2 enzyme, which is responsible for breaking down the toxic substance acetaldehyde , a substance your body metabolizes from alcohol. The build up of ALDH2, which is also responsible for processing histamine, creates a chemical reaction that causes more blood to flow, and that causes the skin to turn red. But this also results in increased heart rate, headaches, and nausea.
Why do some wines cause a flushing or redness on the face and neck?
Skin blushing/flushing: MedlinePlus Medical Encyclopedia
Alcohol flush reaction AFR is a condition in which a person develops flushes or blotches associated with erythema on the face, neck, shoulders, and in some cases, the entire body after consuming alcoholic beverages. The reaction is the result of an accumulation of acetaldehyde , a metabolic byproduct of the catabolic metabolism of alcohol , and is caused by an aldehyde dehydrogenase 2 deficiency. This syndrome has been associated with lower than average rates of alcoholism, possibly due to its association with adverse effects after drinking alcohol. Individuals who experience the alcohol flushing reaction may be less prone to alcoholism. Disulfiram , a drug sometimes given as treatment for alcoholism, works by inhibiting acetaldehyde dehydrogenase , causing a five to tenfold increase in the concentration of acetaldehyde in the body.
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A red face after drinking alcohol may be a warning sign — a new study has found that people who get flushed after drinking are at increased risk for developing high blood pressure. The researchers looked at the risk of hypertension high blood pressure in 1, Korean men, including men who became flush after drinking, who didn't get flush after drinking and who didn't drink. Scientists found that the "flushers" who drank more than four drinks a week had more than double the risk of hypertension , compared with men who didn't drink. In contrast, "nonflushers" had an increased risk of hypertension only if they consumed more than eight alcoholic beverages a week.
Flushing describes episodes of redness of the skin together with a sensation of warmth or burning of the face, neck and, less frequently, the upper trunk. It is the transient nature of the attacks that distinguishes flushing from the more protracted erythema of photosensitivity or contact allergic dermatitis. Flushing can be an exaggeration of a physiological process or much less likely a manifestation of a serious condition that needs to be identified and treated. It is important to consider the clinical characteristics of the flushing before embarking on expensive laboratory evaluation.
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